Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6209469 | 0.86 | CHEK1 (0.52) | CHEK1 | |
| SCHEMBL6210050 | 0.85 | CHEK1 (0.56) | CHEK1 | |
| SCHEMBL4847647 | 0.85 | CHEK1 (0.65) | CHEK1 | |
| SCHEMBL6210672 | 0.83 | CHEK1 (0.48) | CHEK1 | |
| SCHEMBL5431169 | 0.82 | CHEK1 (0.63) | CHEK1 | |
| SCHEMBL6209889 | 0.82 | CHEK1 (0.47) | CHEK1 | |
| SCHEMBL6211141 | 0.81 | CHEK1 (0.46) | CHEK1 | |
| SCHEMBL16712586 | 0.80 | CHEK1 (0.47) | CHEK1 | |
| SCHEMBL6824599 | 0.79 | CHEK1 (0.51) | CHEK1 | |
| SCHEMBL5421646 | 0.79 | CHEK1 (0.44) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606268-A1 | HETEROCYCLIC KINASE INHIBITORS | Abbott Laboratories (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004076424-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-09-10 | — | — | WO | disclosed |