Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 7/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 5/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | IGF1R | P08069 | 4/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212366 | 0.80 | PTK2 (0.63) | PTK2PTK2BEGFRIGF1RFGFR1 | |
| SCHEMBL6216143 | 0.79 | PTK2 (0.75) | PTK2PTK2BEGFRIGF1RFGFR1 | |
| SCHEMBL6210750 | 0.77 | IGF1R (0.49) | PTK2PTK2BIGF1RFGFR1KDR | |
| SCHEMBL6211846 | 0.76 | EGFR (0.53) | PTK2PTK2BEGFRIGF1RFGFR1 | |
| SCHEMBL6212168 | 0.76 | PTK2 (0.52) | PTK2PTK2BIGF1RFGFR1KDR | |
| SCHEMBL6214553 | 0.75 | PTK2 (0.62) | PTK2PTK2BEGFRIGF1RFGFR1 | |
| SCHEMBL6210503 | 0.75 | PTK2 (0.54) | PTK2PTK2BEGFRIGF1RFGFR1 | |
| SCHEMBL6213407 | 0.73 | PTK2 (0.45) | PTK2PTK2BEGFRIGF1RCDK1 | |
| SCHEMBL6209954 | 0.71 | IGF1R (0.51) | PTK2PTK2BEGFRIGF1RFGFR1 | |
| SCHEMBL6211636 | 0.71 | PTK2 (0.44) | PTK2PTK2BEGFRIGF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578732-A2 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056786-A2 | PYRIMIDINE DERIVATES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |