Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207336 | 0.87 | NOTUM (0.48) | NOTUMALDH1A1DYRK1ATDP1RXRA | |
| SCHEMBL4649101 | 0.83 | GRIN2D (0.35) | NOTUMALDH1A1DAODYRK1AGRIN2D | |
| SCHEMBL8705694 | 0.82 | RARB (0.44) | NOTUMALDH1A1MEN1KMT2AHCAR2 | |
| SCHEMBL14334050 | 0.81 | NOTUM (0.46) | NOTUMALDH1A1DAODYRK1ATDP1 | |
| SCHEMBL14333162 | 0.81 | NOTUM (0.46) | NOTUMALDH1A1DAODYRK1ATDP1 | |
| SCHEMBL4649373 | 0.81 | NOTUM (0.42) | NOTUMALDH1A1DYRK1ATDP1MEN1 | |
| SCHEMBL4648846 | 0.80 | NOTUM (0.44) | NOTUMALDH1A1DAODYRK1ATDP1 | |
| SCHEMBL22623624 | 0.79 | CA12 (0.47) | ALDH1A1KDM4EMEN1NPC1KMT2A | |
| SCHEMBL6207170 | 0.79 | NOTUM (0.43) | NOTUMALDH1A1DYRK1ATDP1KDM4E | |
| SCHEMBL14604111 | 0.78 | GAA (0.45) | NOTUMDAOKDM4EMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546133-A2 | N-SUBSTITUTE-2-OXODIHYDROPYRIDINE DERIVATIVES AS NPY ANTAGONISTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004031175-A2 | N-SUBSTITUTED-2-OXODIHYDROPYRIDINE DERIVATIVES AS NPY ANTAGONISTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2004-04-15 | — | — | WO | disclosed |
| US-6670380-B2 | For therapy of insulin resistance, hyperglycemia, hyperinsulinemia, or elevated blood levels of free fatty acids or glycerol, obesity, hypertriglyceridemia, inflammation, atherosclerosis, diabetic retinopathy, diabetic neuropathy | BRISTOL-MYERS SQUIBB CO. | 2003-12-30 | — | — | US | disclosed |
| EP-1343763-A1 | PYRODONE DERIVATIVES AS AP2 INHIBITORS | Bristol-Myers Squibb Company (US) | 2003-09-17 | — | — | EP | disclosed |
| US-20020077340-A1 | Pyridone inhibitors of fatty acid binding protein and method | BRISTOL-MYERS SQUIBB COMPANY | 2002-06-20 | — | — | US | disclosed |
| WO-2002040448-A1 | PYRIDONE DERIVATIVES AS AP2 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077340-A1 | Pyridone inhibitors of fatty acid binding protein and method | FABP1, FABP5, FABP2 | NOTUM 1648/4885ALDH1A1 1579/4885DAO 2624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.