Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1S | P09871 | 7/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 7/20 | 0.36 |
| ▸ | F10 | P00742 | 5/20 | 0.36 |
| ▸ | F2 | P00734 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5840067 | 0.85 | C1S (0.55) | C1SPRSS1PRSS2PRSS3F10 | |
| SCHEMBL8363623 | 0.75 | C1S (0.62) | C1S | |
| Trifluoroacetic Acid SCHEMBL5841624 | 0.73 | C1S (0.66) | C1S | |
| Trifluoroacetic Acid SCHEMBL5840720 | 0.73 | C1S (0.65) | C1S | |
| Trifluoroacetic Acid SCHEMBL5840908 | 0.73 | C1S (0.65) | C1S | |
| Trifluoroacetic Acid SCHEMBL5840978 | 0.73 | C1S (0.64) | C1S | |
| Trifluoroacetic Acid SCHEMBL5841031 | 0.71 | C1S (0.86) | C1S | |
| Trifluoroacetic Acid SCHEMBL5840250 | 0.71 | C1S (0.59) | C1S | |
| Trifluoroacetic Acid SCHEMBL6209316 | 0.70 | C1S (0.59) | C1S | |
| Trifluoroacetic Acid SCHEMBL5840256 | 0.69 | C1S (0.67) | C1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549632-A4 | NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS | DIMENSIONAL PHARM INC (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-1549632-A1 | NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2003099805-A1 | NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2003-12-04 | — | — | WO | disclosed |