Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.72 |
| ▸ | PLK3 | Q9H4B4 | 15/20 | 0.72 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.68 |
| ▸ | CDK2 | P24941 | 1/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.62 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | NEK2 | P51955 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5062036 | 1.00 | PLK1 (0.72) | PLK1PLK3IKBKECDK2PIK3CD | |
| SCHEMBL5067321 | 0.93 | PLK1 (0.68) | PLK1PLK3IKBKECDK2PIK3CD | |
| SCHEMBL6214679 | 0.93 | PLK1 (0.68) | PLK1PLK3IKBKECDK2PIK3CD | |
| SCHEMBL2982244 | 0.91 | PLK1 (0.71) | PLK1PLK3IKBKECDK2PIK3CD | |
| SCHEMBL4395551 | 0.89 | PLK1 (0.69) | PLK1PLK3IKBKECDK2PIK3CD | |
| SCHEMBL4403578 | 0.88 | PLK1 (0.68) | PLK1PLK3IKBKECDK2PIK3CD | |
| SCHEMBL2989088 | 0.88 | PLK1 (0.68) | PLK1PLK3IKBKECDK2PIK3CD | |
| SCHEMBL2973858 | 0.88 | PLK1 (0.68) | PLK1PLK3IKBKECDK2PIK3CD | |
| SCHEMBL3254468 | 0.87 | PLK1 (0.64) | PLK1PLK3IKBKECDK2PIK3CD | |
| SCHEMBL2987942 | 0.87 | PLK1 (0.66) | PLK1PLK3IKBKECDK2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546137-A1 | BENZIMIDAZOL-1-YL-THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER | SmithKline Beecham Corporation (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004014899-A1 | THIOPHENE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-19 | — | — | WO | disclosed |