Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.54 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.49 |
| ▸ | STK4 | Q13043 | 3/20 | 0.46 |
| ▸ | STK3 | Q13188 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5460403 | 0.92 | SRC (0.56) | SRCEGFRERBB2 | |
| Hydrochloric Acid SCHEMBL5490823 | 0.91 | SRC (0.55) | SRCEGFRERBB2 | |
| SCHEMBL5460734 | 0.83 | SRC (0.56) | SRCEGFRERBB2 | |
| Hydrochloric Acid SCHEMBL5485172 | 0.82 | SRC (0.55) | SRCEGFRERBB2 | |
| SCHEMBL4487359 | 0.80 | SRC (0.57) | SRCEGFRERBB2 | |
| SCHEMBL4498795 | 0.79 | SRC (0.63) | SRCEGFRERBB2 | |
| SCHEMBL5452058 | 0.78 | SRC (0.55) | SRCEGFRERBB2 | |
| Hydrochloric Acid SCHEMBL6208463 | 0.77 | SRC (0.55) | SRCEGFRERBB2 | |
| Hydrochloric Acid SCHEMBL5466160 | 0.77 | SRC (0.55) | SRCEGFRERBB2 | |
| SCHEMBL4495250 | 0.77 | SRC (0.60) | SRCEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521751-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS MEK INHIBITORS | Astrazeneca AB (SE) | 2005-04-13 | — | — | EP | claimed |
| WO-2004005284-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS MEK INHIBITORS | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | claimed |