Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5479437 | 0.83 | KMT2A (0.76) | KDM4EKMT2ACYP1A2GAAALDH1A1 | |
| SCHEMBL5489658 | 0.83 | KMT2A (0.72) | KDM4EKMT2ACYP1A2GAAALDH1A1 | |
| SCHEMBL2016910 | 0.83 | KMT2A (1.00) | KDM4EKMT2ACYP1A2GAAALDH1A1 | |
| SCHEMBL5481510 | 0.81 | KMT2A (0.69) | KDM4EKMT2ACYP1A2GAAALDH1A1 | |
| SCHEMBL5477209 | 0.81 | KMT2A (0.73) | KDM4EKMT2ACYP1A2GAAALDH1A1 | |
| SCHEMBL5477051 | 0.80 | KMT2A (0.83) | KDM4EKMT2ACYP1A2GAAALDH1A1 | |
| SCHEMBL5482879 | 0.80 | KMT2A (0.83) | KDM4EKMT2ACYP1A2GAAALDH1A1 | |
| SCHEMBL5486449 | 0.79 | KMT2A (0.81) | KDM4EKMT2ACYP1A2GAAALDH1A1 | |
| SCHEMBL5483247 | 0.79 | KMT2A (0.77) | KDM4EKMT2ACYP1A2GAAALDH1A1 | |
| SCHEMBL5482810 | 0.78 | KMT2A (0.76) | KDM4EKMT2ACYP1A2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351691-A4 | SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA INC (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1351691-A1 | SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | Cytovia, Inc. (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002047690-A1 | SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-06-20 | — | — | WO | disclosed |