Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 11/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | MARK3 | P27448 | 2/20 | 0.42 |
| ▸ | MARK4 | Q96L34 | 2/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212019 | 0.90 | PTK2 (0.61) | CDK1PTK2PTK2BIGF1RFGFR1 | |
| SCHEMBL6209954 | 0.86 | IGF1R (0.51) | CDK1PTK2PTK2BIGF1RFGFR1 | |
| SCHEMBL6210950 | 0.85 | PTK2 (0.49) | CDK1PTK2PTK2BIGF1RFGFR1 | |
| SCHEMBL6210226 | 0.84 | PTK2 (0.61) | PTK2PTK2BIGF1RFGFR1KDR | |
| SCHEMBL6212362 | 0.84 | PTK2 (0.53) | CDK1PTK2PTK2BIGF1RFGFR1 | |
| SCHEMBL6211620 | 0.83 | PTK2 (0.54) | CDK1PTK2PTK2BIGF1RFGFR1 | |
| SCHEMBL6211846 | 0.82 | EGFR (0.53) | CDK1PTK2PTK2BIGF1RFGFR1 | |
| SCHEMBL6214288 | 0.82 | PTK2 (0.49) | CDK1PTK2PTK2BIGF1RFGFR1 | |
| SCHEMBL6211871 | 0.82 | PTK2 (0.53) | CDK1PTK2PTK2BIGF1RFGFR1 | |
| SCHEMBL3450038 | 0.79 | STK17A (0.55) | PTK2PTK2BIGF1RKDRSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578732-A2 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | claimed |
| US-20040220177-A1 | Compound for the treatment of abnormal cell growth | PFIZER INC | 2004-11-04 | — | — | US | claimed |
| WO-2004056786-A2 | PYRIMIDINE DERIVATES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | claimed |
| US-20040220177-A1 | Compound for the treatment of abnormal cell growth | PFIZER INC | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220177-A1 | Compound for the treatment of abnormal cell growth | CCNA1, CCNB1, CCNT1 | CDK1 29/4885PTK2 3004/4885PTK2B 1941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.