Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 16/20 | 0.72 |
| ▸ | PTK2B | Q14289 | 14/20 | 0.70 |
| ▸ | BCL6 | P41182 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | INSR | P06213 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | STK16 | O75716 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212232 | 0.97 | PTK2 (0.67) | PTK2PTK2BBCL6AURKAINSR | |
| SCHEMBL6211063 | 0.95 | PTK2 (0.79) | PTK2PTK2BBCL6AURKAINSR | |
| SCHEMBL6211698 | 0.84 | PTK2 (0.84) | PTK2PTK2BBCL6AURKAINSR | |
| SCHEMBL6211093 | 0.84 | PTK2 (0.84) | PTK2PTK2BBCL6AURKAINSR | |
| SCHEMBL6211546 | 0.84 | PTK2 (0.67) | PTK2PTK2BBCL6AURKAINSR | |
| SCHEMBL6213649 | 0.84 | PTK2 (1.00) | PTK2PTK2BBCL6AURKAINSR | |
| SCHEMBL6209171 | 0.83 | PTK2 (0.80) | PTK2PTK2BBCL6AURKAINSR | |
| SCHEMBL6211830 | 0.83 | PTK2 (1.00) | PTK2PTK2BBCL6AURKAINSR | |
| SCHEMBL6214944 | 0.83 | PTK2 (1.00) | PTK2PTK2BBCL6AURKAINSR | |
| SCHEMBL3163641 | 0.80 | PTK2 (1.00) | PTK2PTK2BBCL6AURKAINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578732-A2 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056786-A2 | PYRIMIDINE DERIVATES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |