Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.44 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6215718 | 0.93 | NPC1 (0.45) | KCNH2 | |
| SCHEMBL5958573 | 0.93 | NPC1 (0.45) | KCNH2 | |
| SCHEMBL5958631 | 0.78 | KCNH2 (0.62) | KCNH2 | |
| SCHEMBL5958598 | 0.78 | KCNH2 (0.62) | KCNH2 | |
| SCHEMBL5958596 | 0.78 | KCNH2 (0.62) | KCNH2 | |
| Hydrochloric Acid SCHEMBL5958619 | 0.77 | KCNH2 (0.58) | KCNH2 | |
| SCHEMBL5958522 | 0.75 | KCNH2 (0.58) | KCNH2S1PR1 | |
| SCHEMBL5958344 | 0.75 | KCNH2 (0.62) | KCNH2 | |
| Hydrochloric Acid SCHEMBL5958725 | 0.74 | KCNH2 (0.61) | KCNH2 | |
| SCHEMBL5958660 | 0.74 | KCNH2 (0.61) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1536790-A2 | OXADIAZOLES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | AstraZeneca AB (SE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004014370-A2 | OXADIAZOLES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | ASTRAZENECA AB (SE) | 2004-02-19 | — | — | WO | disclosed |