Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 11/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989748 | 0.83 | MAPT (0.54) | KDRMAPTALDH1A1MAPK9MAPK10 | |
| SCHEMBL4830332 | 0.82 | KDR (0.41) | KDRMAPTALDH1A1MAPK9MAPK10 | |
| SCHEMBL6210942 | 0.71 | HPGD (0.38) | KDRMAPTALDH1A1MAPK9MAPK10 | |
| SCHEMBL17743800 | 0.70 | SMN1; SMN2 (0.55) | MAPTALDH1A1MAPK9MAPK10SMN1; SMN2 | |
| SCHEMBL4833774 | 0.67 | KDR (0.43) | KDRMAPK9MAPK10 | |
| SCHEMBL988469 | 0.66 | MAPK9 (0.45) | KDRMAPK9MAPK10 | |
| SCHEMBL25442750 | 0.66 | MAPK9 (0.56) | KDRMAPTMAPK9MAPK10 | |
| SCHEMBL23903288 | 0.66 | MAPK9 (0.53) | KDRALDH1A1MAPK9MAPK10CYP1A2 | |
| SCHEMBL23903552 | 0.65 | MAPK9 (0.51) | KDRMAPK9MAPK10 | |
| SCHEMBL25442243 | 0.64 | MAPK9 (0.51) | KDRMAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004014900-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2004-02-19 | — | — | WO | disclosed |