Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.68 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.68 |
| ▸ | PLK4 | O00444 | 2/20 | 0.68 |
| ▸ | AURKA | O14965 | 2/20 | 0.68 |
| ▸ | JAK2 | O60674 | 2/20 | 0.68 |
| ▸ | LCK | P06239 | 2/20 | 0.68 |
| ▸ | CSF1R | P07333 | 2/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.68 |
| ▸ | SRC | P12931 | 2/20 | 0.68 |
| ▸ | FLT1 | P17948 | 2/20 | 0.68 |
| ▸ | CDK2 | P24941 | 2/20 | 0.68 |
| ▸ | AXL | P30530 | 2/20 | 0.68 |
| ▸ | FLT4 | P35916 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 2/20 | 0.68 |
| ▸ | GSK3B | P49841 | 2/20 | 0.68 |
| ▸ | NEK2 | P51955 | 2/20 | 0.68 |
| ▸ | JAK3 | P52333 | 2/20 | 0.68 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.68 |
| ▸ | STK3 | Q13188 | 2/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5058228 | 0.92 | PLK1 (0.66) | PLK1PLK3PLK4AURKAJAK2 | |
| SCHEMBL5058177 | 0.88 | PLK1 (0.59) | PLK1PLK3PLK4AURKAJAK2 | |
| SCHEMBL4034945 | 0.82 | PLK1 (0.78) | PLK1PLK3PLK4AURKAJAK2 | |
| SCHEMBL5062148 | 0.82 | PLK1 (0.59) | PLK1PLK3PLK4AURKAJAK2 | |
| SCHEMBL5067346 | 0.81 | PLK1 (0.85) | PLK1PLK3PLK4AURKAJAK2 | |
| SCHEMBL5058278 | 0.81 | PLK1 (1.00) | PLK1PLK3PLK4AURKAJAK2 | |
| SCHEMBL5065696 | 0.80 | PLK1 (0.59) | PLK1PLK3PLK4AURKAJAK2 | |
| SCHEMBL5062883 | 0.78 | PLK1 (0.68) | PLK1PLK3PLK4AURKAJAK2 | |
| SCHEMBL5062393 | 0.78 | PLK1 (0.68) | PLK1PLK3PLK4AURKAJAK2 | |
| SCHEMBL5058138 | 0.77 | PLK1 (0.88) | PLK1PLK3PLK4AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546137-A1 | BENZIMIDAZOL-1-YL-THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER | SmithKline Beecham Corporation (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004014899-A1 | THIOPHENE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-19 | — | — | WO | disclosed |