Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6590820 | 1.00 | EPHX1 (0.40) | EPHX1MEN1GAAKMT2AGLA | |
| SCHEMBL3956518 | 0.85 | CYP2C9 (0.33) | GAAGLA | |
| SCHEMBL6212033 | 0.84 | EPHX1 (0.39) | EPHX1MEN1GAAKMT2AGLA | |
| SCHEMBL6590314 | 0.82 | GLA (0.31) | GLA | |
| SCHEMBL6589776 | 0.81 | TDP1 (0.44) | EPHX1MEN1GAAKMT2ATDP1 | |
| SCHEMBL6589768 | 0.81 | TDP1 (0.44) | EPHX1MEN1GAAKMT2ATDP1 | |
| SCHEMBL7427599 | 0.80 | MEN1 (0.46) | MEN1GAAKMT2AF10PRSS1 | |
| SCHEMBL14040699 | 0.78 | BTK (0.42) | EPHX1GAAHDAC4HDAC6 | |
| SCHEMBL4765504 | 0.78 | BTK (0.42) | EPHX1GAAHDAC4HDAC6 | |
| SCHEMBL14131624 | 0.78 | BTK (0.42) | EPHX1GAAHDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307203-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1307203-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2001070232-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-27 | — | — | WO | disclosed |