Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212719 | 0.93 | MAPT (0.43) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL6216029 | 0.89 | MAPT (0.48) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL6213381 | 0.87 | PRKCI (0.46) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL6211763 | 0.87 | KMT2A (0.61) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL6212974 | 0.86 | PDE5A (0.53) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL6792490 | 0.86 | MAPT (0.44) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL6214632 | 0.85 | MAPT (0.47) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL6217931 | 0.85 | MAPT (0.47) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL6214819 | 0.85 | KMT2A (0.48) | MAPTMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL6210438 | 0.85 | KMT2A (0.48) | MAPTMEN1KMT2ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351962-B1 | THIENOPYRIMIDINE | MERCK PATENT GMBH (DE) | 2005-03-16 | — | — | EP | disclosed |
| US-6780867-B2 | THEY EXHIBIT SPECIFIC INHIBITION OF CGMP PHOSPHODIESTERASE (PDE V) | MERCK PATENT GMBH (DE) | 2004-08-24 | — | — | US | disclosed |
| US-20030187260-A1 | Thienopyrimidines | MERCK PATENT GMBH (DE) | 2003-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187260-A1 | Thienopyrimidines | TYMP, DPYD, IMPDH1 | MAPT 4330/4885MEN1 2082/4885KMT2A 3197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.