Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 9/20 | 0.58 |
| ▸ | ITGB2 | P05107 | 8/20 | 0.58 |
| ▸ | ICAM1 | P05362 | 8/20 | 0.58 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 3/20 | 0.33 |
| ▸ | HTR1B | P28222 | 2/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197971 | 0.85 | ITGAL (0.65) | ITGALITGB2ICAM1ENPP2 | |
| SCHEMBL6220680 | 0.79 | ITGAL (0.54) | ITGALITGB2ICAM1ENPP2 | |
| SCHEMBL6219468 | 0.78 | ITGAL (0.52) | ITGALITGB2ICAM1ENPP2 | |
| SCHEMBL6199888 | 0.77 | ITGAL (0.41) | ITGALITGB2ICAM1ENPP2ALDH1A1 | |
| SCHEMBL6221367 | 0.75 | ITGB2 (0.52) | ITGALITGB2ICAM1KDM4EMEN1 | |
| SCHEMBL6248060 | 0.74 | ITGAL (0.58) | ITGALITGB2ICAM1ENPP2KMT2A | |
| SCHEMBL6197975 | 0.73 | ITGAL (1.00) | ITGALITGB2ICAM1 | |
| SCHEMBL27476332 | 0.73 | ITGAL (1.00) | ITGALITGB2ICAM1 | |
| SCHEMBL6219298 | 0.73 | ITGAL (0.54) | ITGALITGB2ICAM1ENPP2ALDH1A1 | |
| SCHEMBL6219596 | 0.71 | ITGAL (0.57) | ITGALITGB2ICAM1ENPP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140814-B1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | claimed |