Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 20/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 14/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6861124 | 0.85 | ADORA2A (0.71) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6859592 | 0.83 | ADORA2A (0.70) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6216685 | 0.82 | ADORA2A (0.72) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6217941 | 0.82 | ADORA2A (0.64) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6852945 | 0.80 | ADORA2A (0.71) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6217242 | 0.78 | ADORA2A (1.00) | ADORA2AADORA1 | |
| SCHEMBL6852837 | 0.76 | ADORA2A (0.76) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6214990 | 0.75 | ADORA2A (1.00) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6852789 | 0.75 | ADORA2A (0.68) | ADORA2AADORA1ADORA2B | |
| SCHEMBL6859881 | 0.75 | ADORA2A (0.70) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192164-B1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RES LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| US-6787541-B1 | MOVEMENT DISORDERS, PARKINSON'S DISEASE | VERNALIS RESEARCH LIMITED (GB) | 2004-09-07 | — | — | US | disclosed |