⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2419687 | 0.97 | — | — | |
| SCHEMBL6221724 | 0.84 | — | — | |
| SCHEMBL2419507 | 0.81 | — | — | |
| SCHEMBL2420827 | 0.79 | — | — | |
| SCHEMBL2420826 | 0.79 | — | — | |
| SCHEMBL2420999 | 0.79 | TRPV1 (0.48) | — | |
| SCHEMBL2415673 | 0.78 | EPHX2 (0.51) | — | |
| SCHEMBL2420762 | 0.77 | — | — | |
| SCHEMBL2419106 | 0.76 | — | — | |
| SCHEMBL2419249 | 0.76 | TRPV1 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551811-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS VANILLOID RECEPTOR LIGANDS | Amgen Inc. (US) | 2005-07-13 | — | — | EP | claimed |
| US-20040152690-A1 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. | 2004-08-05 | — | — | US | claimed |
| WO-2004035549-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS VANILLOID RECEPTOR LIGANDS | AMGEN INC. (US) | 2004-04-29 | — | — | WO | claimed |