Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 14/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6219992 | 0.89 | CYP2C9 (0.52) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6221440 | 0.85 | CYP2C9 (0.53) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5778750 | 0.84 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6608672 | 0.83 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6220307 | 0.83 | CYP2C9 (0.60) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6220002 | 0.82 | CYP2C9 (0.60) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6633535 | 0.82 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6219420 | 0.82 | CYP2C9 (0.55) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5776445 | 0.82 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6220354 | 0.82 | CYP2C9 (0.49) | PDE4APDE4BPDE4CPDE4DCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517895-A1 | 8-(BIARYL) QUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000814-A1 | 8-(BIARYL) QUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2003-12-31 | — | — | WO | disclosed |