Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.76 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.76 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.76 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.76 |
| ▸ | AKT1 | P31749 | 7/20 | 0.47 |
| ▸ | AKT2 | P31751 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6214877 | 0.86 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6218385 | 0.84 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6217730 | 0.84 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6216277 | 0.83 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11AKT1 | |
| SCHEMBL6216415 | 0.81 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4863569 | 0.79 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11AKT1 | |
| SCHEMBL6215685 | 0.77 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL18691313 | 0.76 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11AKT1 | |
| SCHEMBL6216442 | 0.74 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11AKT1 | |
| SCHEMBL6220623 | 0.74 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140939-B1 | SUBSTITUTED 2-ARYL-3-(HETEROARYL)-IMIDAZO[1,2-ALPHA]PYRIMIDINES, AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS | ORTHO MCNEIL PHARM INC (US) | 2005-02-09 | — | — | EP | claimed |
| US-6610697-B1 | Treating rheumatoid arthritis | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-08-26 | — | — | US | claimed |
| EP-1140939-B1 | SUBSTITUTED 2-ARYL-3-(HETEROARYL)-IMIDAZO[1,2-ALPHA]PYRIMIDINES, AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS | ORTHO MCNEIL PHARM INC (US) | 2005-02-09 | — | — | EP | disclosed |
| US-6610697-B1 | Treating rheumatoid arthritis | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1140939-A1 | SUBSTITUTED 2-ARYL-3-(HETEROARYL)-IMIDAZO[1,2-ALPHA]PYRIMIDINES, AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2001034605-A1 | SUBSTITUTED 2-ARYL-3-(HETEROARYL)-IMIDAZO[1,2-a]PYRIMIDINES, AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-05-17 | — | — | WO | disclosed |