Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 5/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 5/20 | 0.36 |
| ▸ | ITGAL | P20701 | 5/20 | 0.36 |
| ▸ | CCR2 | P41597 | 4/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 4/20 | 0.33 |
| ▸ | ACHE | P22303 | 4/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220099 | 0.92 | CYP2C19 (0.35) | ITGB2ICAM1ITGALCCR2CYP2C19 | |
| SCHEMBL6224126 | 0.91 | ITGB2 (0.34) | ITGB2ICAM1ITGALCCR2CYP2C19 | |
| SCHEMBL6194325 | 0.85 | ITGB2 (0.43) | ITGB2ICAM1ITGALCCR2CYP2C19 | |
| SCHEMBL6221073 | 0.85 | ITGB2 (0.37) | ITGB2ICAM1ITGALCCR2CYP2C19 | |
| SCHEMBL6220880 | 0.83 | ITGB2 (0.53) | ITGB2ICAM1ITGALRAB9A | |
| SCHEMBL6199984 | 0.78 | ITGB2 (0.40) | ITGB2ICAM1ITGALCCR2CYP2C19 | |
| SCHEMBL6198713 | 0.77 | ITGB2 (0.41) | ITGB2ICAM1ITGALCYP2C19PDK2 | |
| SCHEMBL6219459 | 0.73 | HRH3 (0.40) | LMNA | |
| SCHEMBL6196672 | 0.70 | ITGB2 (0.45) | ITGB2ICAM1ITGALCYP2C19CYP3A4 | |
| SCHEMBL6568653 | 0.69 | ITGB2 (0.45) | ITGB2ICAM1ITGALCCR2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140814-B1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | claimed |