Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 2/20 | 1.00 |
| ▸ | GSK3B | P49841 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | NAT1 | P18440 | 2/20 | 0.75 |
| ▸ | MRE11 | P49959 | 1/20 | 0.75 |
| ▸ | PNP | P00491 | 1/20 | 0.72 |
| ▸ | PIM1 | P11309 | 5/20 | 0.70 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.70 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.70 |
| ▸ | MAOA | P21397 | 3/20 | 0.68 |
| ▸ | MAOB | P27338 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | NSD2 | O96028 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL621989 | 1.00 | TDP1 (1.00) | TDP1HPGDAKR1B1GSK3BRAB9A | |
| SCHEMBL621991 | 1.00 | TDP1 (1.00) | TDP1HPGDAKR1B1GSK3BRAB9A | |
| SCHEMBL8534665 | 0.86 | NAT1 (1.00) | TDP1HPGDAKR1B1GSK3BRAB9A | |
| Mirin SCHEMBL15421606 | 0.86 | MRE11 (1.00) | TDP1HPGDAKR1B1GSK3BRAB9A | |
| Mirin SCHEMBL21296287 | 0.86 | MRE11 (1.00) | TDP1HPGDAKR1B1GSK3BRAB9A | |
| SCHEMBL8174883 | 0.86 | NAT1 (1.00) | TDP1HPGDAKR1B1GSK3BRAB9A | |
| SCHEMBL8174880 | 0.86 | NAT1 (1.00) | TDP1HPGDAKR1B1GSK3BRAB9A | |
| Mirin SCHEMBL15421605 | 0.86 | MRE11 (1.00) | TDP1HPGDAKR1B1GSK3BRAB9A | |
| SCHEMBL1249051 | 0.85 | GSK3B (0.73) | TDP1HPGDAKR1B1GSK3BRAB9A | |
| SCHEMBL1249053 | 0.85 | GSK3B (0.73) | TDP1HPGDAKR1B1GSK3BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 164 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216148-B2 | Compound having skin-whitening, anti-oxidizing and PPAR activities and medical use therefor | PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) | 2015-12-22 | — | — | US | claimed |
| US-20140023603-A1 | NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR | PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION (KR) | 2014-01-23 | — | — | US | claimed |
| WO-2009148195-A1 | 5-(4-HYDROXYBENZYL)THIAZOLIDINE-2,4-DIONE AS INTERMEDIATE FOR SYNTHESIS OF THIAZOLIDINEDIONE BASED COMPOUNDS AND PROCESS FOR PREPARING THE SAME | DAEBONG LS, LTD. (KR) | 2009-12-10 | — | — | WO | claimed |
| JP-8277279-A | — | — | None | — | — | JP | disclosed |
| CN-115433144-B | Fatty acid ester compound and preparation method and application thereof | 燃点(南京)生物医药科技有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-115433144-A | Fatty acid ester compound and preparation method and application thereof | 燃点(南京)生物医药科技有限公司 | 2022-12-06 | — | — | CN | disclosed |
| CN-113368828-B | Air purification material of MOF framework carbonization heterojunction and preparation method and application thereof | 北京航天河科技发展有限公司 | 2021-11-05 | — | — | CN | disclosed |
| CN-113368828-A | Air purification material of MOF framework carbonization heterojunction and preparation method and application thereof | 北京航天河科技发展有限公司 | 2021-09-10 | — | — | CN | disclosed |
| US-10787425-B2 | Thiazolidinedione derivative and use thereof | INDUSTRY-ACADEMIC COOPERATION FOUNDATION CHOSUN UNIVERSITY (KR) | 2020-09-29 | — | — | US | disclosed |
| US-10787425-B2 | Thiazolidinedione derivative and use thereof | INDUSTRY-ACADEMIC COOPERATION FOUNDATION CHOSUN UNIVERSITY (KR) | 2020-09-29 | — | — | US | disclosed |
| US-20190016695-A1 | THIAZOLIDINEDIONE DERIVATIVE AND USE THEREOF | INDUSTRY-ACADEMIC COOPERATION FOUNDATION CHOSUN UNIVERSITY (KR) | 2019-01-17 | — | — | US | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |
| EP-0839812-A1 | Preparation of benzylthiazolidine derivatives | Sankyo Company Limited (JP) | 1998-05-06 | — | — | EP | disclosed |
| JP-H08277279-A | PRODUCTION OF BENZYLTHIAZOLIDINDIONE DERIVATIVE | NITTO CHEM IND CO LTD | 1996-10-22 | — | — | JP | disclosed |
| US-5387596-A | Treating arteriosclerosis | SANKYO COMPANY, LIMITED (JP) | 1995-02-07 | — | — | US | disclosed |
| EP-0454501-A2 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | Sankyo Company Limited (JP) | 1991-10-30 | — | — | EP | disclosed |
| EP-0177353-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1990-04-11 | — | — | EP | disclosed |
| US-4725610-A | TREATMENT OF HYPERLIPEMIA AND DIABETES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0177353-A2 | Thiazolidinedione derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1986-04-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140023603-A1 | NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR | PPARG, PPARA, PPARD | TDP1 1138/4885HPGD 489/4885AKR1B1 958/4885 |
| US-20190016695-A1 | THIAZOLIDINEDIONE DERIVATIVE AND USE THEREOF | PPARD, SLC5A2, SLC5A1 | TDP1 4537/4885HPGD 819/4885AKR1B1 532/4885 |
| US-10787425-B2 | Thiazolidinedione derivative and use thereof | PPARD, SLC5A2, SLC5A1 | TDP1 4537/4885HPGD 819/4885AKR1B1 532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.