Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 9/20 | 0.50 |
| ▸ | PPARA | Q07869 | 8/20 | 0.50 |
| ▸ | PPARG | P37231 | 6/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1672348 | 0.89 | FFAR1 (0.47) | PPARDPPARAPPARGFFAR1NPC1 | |
| SCHEMBL6220642 | 0.85 | PPARD (0.48) | PPARDPPARAPPARGFFAR1NPC1 | |
| SCHEMBL2463065 | 0.84 | FFAR1 (0.45) | PPARDPPARAPPARGFFAR1NPC1 | |
| SCHEMBL1672351 | 0.84 | FFAR1 (0.45) | PPARDPPARAPPARGFFAR1NPC1 | |
| SCHEMBL3374725 | 0.82 | MAPT (0.60) | PPARDPPARAPPARGFFAR1NPC1 | |
| SCHEMBL24658286 | 0.82 | PPARD (0.45) | PPARDPPARAPPARGFFAR1NPC1 | |
| SCHEMBL30003995 | 0.82 | PPARD (0.45) | PPARDPPARAPPARGFFAR1NPC1 | |
| SCHEMBL6221366 | 0.81 | FFAR1 (0.45) | PPARDPPARAPPARGFFAR1NPC1 | |
| SCHEMBL24742098 | 0.81 | PPARD (0.43) | PPARDPPARAPPARGFFAR1NPC1 | |
| SCHEMBL24658514 | 0.80 | PPARD (0.49) | PPARDPPARAPPARGFFAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581521-A1 | FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-05 | — | — | EP | disclosed |
| EP-1581491-A1 | INDOLE DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004092131-A1 | INDOLE DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-10-28 | — | — | WO | disclosed |
| WO-2004063190-A1 | FUSED HETEROCYCLIC DERIVATES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |