Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 1.00 |
| ▸ | RAF1 | P04049 | 2/20 | 0.56 |
| ▸ | BRAF | P15056 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223233 | 0.90 | MAPK14 (0.81) | MAPK14RAF1BRAF | |
| SCHEMBL6220523 | 0.88 | MAPK14 (0.79) | MAPK14RAF1BRAF | |
| SCHEMBL6222906 | 0.88 | MAPK14 (1.00) | MAPK14RAF1BRAF | |
| SCHEMBL6225054 | 0.87 | MAPK14 (1.00) | MAPK14RAF1BRAF | |
| SCHEMBL6222000 | 0.86 | MAPK14 (0.76) | MAPK14RAF1BRAF | |
| SCHEMBL6221423 | 0.85 | MAPK14 (0.81) | MAPK14 | |
| SCHEMBL5897801 | 0.84 | MAPK14 (0.79) | MAPK14RAF1BRAF | |
| SCHEMBL6221291 | 0.84 | MAPK14 (0.76) | MAPK14RAF1BRAF | |
| SCHEMBL7841389 | 0.83 | MAPK14 (0.71) | MAPK14RAF1BRAF | |
| SCHEMBL6294526 | 0.83 | MAPK14 (1.00) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100415724-C | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | CN | claimed |
| US-6846827-B1 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-01-25 | — | — | US | claimed |
| EP-1226126-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-01-05 | — | — | EP | claimed |
| CN-1378537-A | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2002-11-06 | — | — | CN | claimed |
| EP-1226126-A1 | PYRIMIDINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-31 | — | — | EP | claimed |
| WO-2001027089-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-04-19 | — | — | WO | claimed |
| CN-100415724-C | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | CN | disclosed |
| US-6846827-B1 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-01-25 | — | — | US | disclosed |
| EP-1226126-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-01-05 | — | — | EP | disclosed |
| CN-1378537-A | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2002-11-06 | — | — | CN | disclosed |
| EP-1226126-A1 | PYRIMIDINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001027089-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-04-19 | — | — | WO | disclosed |