Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 15/20 | 0.67 |
| ▸ | CLK2 | P49760 | 8/20 | 0.67 |
| ▸ | CLK3 | P49761 | 7/20 | 0.67 |
| ▸ | WNT1 | P04628 | 10/20 | 0.60 |
| ▸ | GSK3B | P49841 | 5/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.48 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.48 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4523534 | 0.87 | DYRK1A (0.53) | DYRK1ACLK2CLK3WNT1GSK3B | |
| SCHEMBL5915922 | 0.83 | DYRK1A (0.52) | DYRK1ACLK2CLK3WNT1GSK3B | |
| SCHEMBL952067 | 0.82 | DYRK1A (0.55) | DYRK1ACLK2CLK3WNT1GSK3B | |
| SCHEMBL14792212 | 0.82 | DYRK1A (0.74) | DYRK1ACLK2CLK3WNT1 | |
| SCHEMBL14792242 | 0.82 | DYRK1A (0.79) | DYRK1ACLK2CLK3WNT1GSK3B | |
| SCHEMBL22252956 | 0.80 | DYRK1A (1.00) | DYRK1ACLK2CLK3WNT1 | |
| SCHEMBL14792378 | 0.79 | DYRK1A (0.67) | DYRK1ACLK2CLK3WNT1GSK3B | |
| SCHEMBL17096832 | 0.79 | DYRK1A (0.69) | DYRK1ACLK2CLK3WNT1GSK3B | |
| SCHEMBL14792853 | 0.79 | DYRK1A (0.73) | DYRK1ACLK2CLK3WNT1GSK3B | |
| SCHEMBL14792077 | 0.78 | DYRK1A (0.82) | DYRK1ACLK2CLK3WNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549620-A1 | INDAZOLECARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF AS CDK1, CDK2 AND CDK4 INHIBITORS | Sanofi-Aventis (FR) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004031158-A1 | INDAZOLECARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF AS CDK1, CDK2 AND CDK4 INHIBITORS | SANOFI-AVENTIS (FR) | 2004-04-15 | — | — | WO | disclosed |