Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 4/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.41 |
| ▸ | RET | P07949 | 4/20 | 0.40 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220940 | 0.92 | PDGFRB (0.48) | NTRK1NTRK2NTRK3PDGFRBKCNH2 | |
| SCHEMBL6224467 | 0.91 | NTRK1 (0.50) | NTRK1NTRK2NTRK3PDGFRBKCNH2 | |
| SCHEMBL6223880 | 0.91 | PDGFRB (0.49) | NTRK1NTRK2NTRK3PDGFRBKCNH2 | |
| SCHEMBL6220911 | 0.91 | PDGFRB (0.53) | NTRK1NTRK2NTRK3PDGFRBKCNH2 | |
| SCHEMBL6218885 | 0.89 | NTRK1 (0.47) | NTRK1NTRK2NTRK3PDGFRBKCNH2 | |
| SCHEMBL6222445 | 0.89 | NTRK1 (0.46) | NTRK1NTRK2NTRK3PDGFRBKCNH2 | |
| SCHEMBL5364437 | 0.88 | NTRK1 (0.48) | NTRK1NTRK2NTRK3PDGFRBKCNH2 | |
| SCHEMBL6223276 | 0.87 | PDGFRB (0.46) | NTRK1NTRK2NTRK3PDGFRBKCNH2 | |
| SCHEMBL5350777 | 0.87 | PDGFRB (0.49) | NTRK1NTRK2NTRK3PDGFRBKCNH2 | |
| SCHEMBL6220539 | 0.87 | PDGFRB (0.55) | NTRK1NTRK2NTRK3PDGFRBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-A1 | PYRROLOPYRIMIDINE DERIVATIVES | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | claimed |
| WO-2004056830-A1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | claimed |
| EP-1578751-A1 | PYRROLOPYRIMIDINE DERIVATIVES | Pfizer Products Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056830-A1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |