Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.63 |
| ▸ | GABRP | O00591 | 4/20 | 0.46 |
| ▸ | GABRD | O14764 | 4/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.46 |
| ▸ | GABRE | P78334 | 4/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223204 | 0.82 | CNR2 (0.45) | CNR2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2214750 | 0.82 | CNR2 (0.71) | CNR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2214063 | 0.82 | CNR2 (0.77) | CNR2GABRPGABRDGABRA1GABRB1 | |
| Hydrochloric Acid SCHEMBL27908737 | 0.81 | CNR2 (0.70) | CNR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7684633 | 0.80 | CNR2 (0.63) | CNR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL16120076 | 0.80 | CNR2 (0.85) | CNR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2216873 | 0.80 | CNR2 (0.67) | CNR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5849866 | 0.79 | CNR2 (0.66) | CNR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2212394 | 0.78 | CNR2 (0.94) | CNR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL6222850 | 0.78 | CNR2 (0.62) | CNR2GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137413-B1 | NON-PEPTIDE ANTAGONISTS OF GLP-1 RECEPTOR AND METHODS OF USE | AGOURON PHARMA (US) | 2005-02-02 | — | — | EP | disclosed |
| US-6469021-B1 | ANTAGONISTS OF THE INTESTINAL HORMONE GLUCAGONS-LIKE PEPTIDE 1 (GLP-1) HAVE A 9H-B-CARBOLINE CENTRAL MOTIF, FOR REGULATING THE SECRETION OF INSULIN IN DIABETIC PATIENTS | AGOURON PHARMACEUTICALS, INC. | 2002-10-22 | — | — | US | disclosed |
| EP-1137413-A4 | NON-PEPTIDE ANTAGONISTS OF GLP-1 RECEPTOR AND METHODS OF USE | AGOURON PHARMA (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1137413-A2 | NON-PEPTIDE ANTAGONISTS OF GLP-1 RECEPTOR AND METHODS OF USE | AGOURON PHARMACEUTICALS, INC. (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000033839-A1 | NON-PEPTIDE ANTAGONISTS OF GLP-1 RECEPTOR AND METHODS OF USE | AGOURON PHARMACEUTICALS, INC. (US) | 2000-06-15 | — | — | WO | disclosed |