Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | RAD52 | P43351 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL320907 | 0.90 | KDM4E (0.69) | KDM4EGAAALDH1A1HPGDPOLB | |
| SCHEMBL29446754 | 0.90 | KDM4E (0.69) | KDM4EGAAALDH1A1HPGDPOLB | |
| SCHEMBL601351 | 0.88 | KDM4E (0.67) | KDM4EGAAALDH1A1HPGDPOLB | |
| SCHEMBL320922 | 0.88 | KDM4E (0.67) | KDM4EGAAALDH1A1HPGDPOLB | |
| SCHEMBL321157 | 0.88 | KDM4E (0.67) | KDM4EGAAALDH1A1HPGDPOLB | |
| SCHEMBL194341 | 0.88 | KDM4E (0.67) | KDM4EGAAALDH1A1HPGDPOLB | |
| SCHEMBL600275 | 0.88 | KDM4E (0.67) | KDM4EGAAALDH1A1HPGDPOLB | |
| SCHEMBL599897 | 0.88 | KDM4E (0.67) | KDM4EGAAALDH1A1HPGDPOLB | |
| SCHEMBL194585 | 0.88 | KDM4E (0.67) | KDM4EGAAALDH1A1HPGDPOLB | |
| SCHEMBL321523 | 0.88 | KDM4E (0.67) | KDM4EGAAALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142902-B1 | 3'-derivatised oligonucleotide analogues with non-nucleotidic groups, their preparation and use | AVENTIS PHARMA GMBH (DE) | 2005-10-26 | — | — | EP | disclosed |
| EP-0552766-B1 | Oligonucleotide analogues, their preparation and use | AVENTIS PHARMA GMBH (DE) | 2002-05-22 | — | — | EP | disclosed |
| EP-1142902-A2 | 3'-Derivatised oligonucleotide analogues with non-nucleotidic groups, their preparation and use | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-10-10 | — | — | EP | disclosed |
| US-6033909-A | INHIBITORS OF GENE EXPRESSION | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-03-07 | — | — | US | disclosed |
| US-5646261-A | PHOSPHORUS DERIVATIZED; ANTISENSE AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-07-08 | — | — | US | disclosed |
| EP-0552766-A2 | Oligonucleotide analogues, their preparation and use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-28 | — | — | EP | disclosed |
| EP-0552767-A2 | 3'-derivatised oligonucleotide analogues with non-nucleotidic groups, their preparation and use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-28 | — | — | EP | disclosed |