Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.47 |
| ▸ | BRAF | P15056 | 4/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | TEK | Q02763 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.38 |
| ▸ | YES1 | P07947 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223721 | 0.91 | KDR (0.46) | KDRBRAFKITTEKLMNA | |
| SCHEMBL1115271 | 0.87 | KDR (0.56) | KDRBRAFKITLMNAMEN1 | |
| SCHEMBL1577802 | 0.87 | KDR (0.65) | KDRBRAFKITTNNI3KYES1 | |
| SCHEMBL6223810 | 0.85 | KDR (0.51) | KDRBRAFKITLMNAMEN1 | |
| SCHEMBL5262308 | 0.81 | TEK (0.54) | KDRKITTEKYES1ABL1 | |
| SCHEMBL13417761 | 0.81 | KDR (0.47) | KDRBRAFKITTEKLMNA | |
| SCHEMBL3149959 | 0.81 | KDR (0.47) | KDRBRAFKITTEKLMNA | |
| SCHEMBL3150889 | 0.81 | KDR (0.47) | KDRBRAFKITTEKLMNA | |
| SCHEMBL3155284 | 0.81 | KDR (0.47) | KDRBRAFKITTEKLMNA | |
| SCHEMBL3154554 | 0.81 | KDR (0.47) | KDRBRAFKITTEKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537084-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | Amgen Inc. (US) | 2005-06-08 | — | — | EP | claimed |
| WO-2004007458-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | AMGEN INC. (US) | 2004-01-22 | — | — | WO | claimed |
| EP-1537084-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | Amgen Inc. (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004007458-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | AMGEN INC. (US) | 2004-01-22 | — | — | WO | disclosed |