Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.45 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.45 |
| ▸ | CIT | O14578 | 1/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | STK10 | O94804 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | YES1 | P07947 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | HCK | P08631 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | FGR | P09769 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6228121 | 1.00 | KDR (0.48) | KDRRETMAP3K20RIPK3CIT | |
| SCHEMBL6224194 | 1.00 | KDR (0.48) | KDRRETMAP3K20RIPK3CIT | |
| SCHEMBL6226125 | 0.95 | KDR (0.53) | KDRRETMAP3K20RIPK3CIT | |
| SCHEMBL6226820 | 0.94 | KDR (0.41) | KDRRETMAP3K20RIPK3CIT | |
| SCHEMBL6225538 | 0.94 | KDR (0.41) | KDRRETMAP3K20RIPK3CIT | |
| SCHEMBL6222361 | 0.94 | KDR (0.48) | KDRRETMAP3K20RIPK3CIT | |
| SCHEMBL6222003 | 0.90 | KDR (0.49) | KDRRETMAP3K20RIPK3CIT | |
| SCHEMBL6227086 | 0.88 | PDPK1 (0.43) | KDRRETMAP3K20RIPK3CIT | |
| SCHEMBL5553710 | 0.88 | KDR (0.39) | KDRRETMAP3K20RIPK3CIT | |
| SCHEMBL5266145 | 0.86 | MAPT (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537084-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | Amgen Inc. (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004007458-A1 | SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF | AMGEN INC. (US) | 2004-01-22 | — | — | WO | disclosed |