Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.60 |
| ▸ | MAP2K2 | P36507 | 10/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25143268 | 0.91 | MAP2K1 (0.72) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 | |
| SCHEMBL30793061 | 0.91 | MAP2K1 (0.72) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 | |
| SCHEMBL6137847 | 0.88 | MAP2K1 (0.60) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 | |
| SCHEMBL4858006 | 0.88 | PIM1 (0.71) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 | |
| SCHEMBL5398785 | 0.88 | MAP2K1 (0.66) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 | |
| SCHEMBL6232002 | 0.88 | MAP2K1 (0.57) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 | |
| SCHEMBL5388138 | 0.87 | MAP2K1 (0.60) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 | |
| SCHEMBL6138222 | 0.87 | MAP2K1 (0.60) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 | |
| SCHEMBL5378886 | 0.86 | MAP2K1 (0.60) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 | |
| SCHEMBL5390991 | 0.86 | MAP2K1 (0.69) | MAP2K1MAP2K2PIM1CAMK2BHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140291-B1 | COMBINATION CHEMOTHERAPY COMPRISING A MITOTIC INHIBITOR AND A MEK INHIBITOR | WARNER LAMBERT CO (US) | 2005-11-23 | — | — | EP | disclosed |
| EP-1140062-B1 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER LAMBERT CO (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-0993439-B1 | 4-BROMO OR 4-IODO PHENYLAMINO BENZHYDROXAMIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS | WARNER LAMBERT CO (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1202726-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005392-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |