Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.53 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.40 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.39 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851804 | 0.89 | MAP2K1 (0.54) | MAP2K1IDO1MEN1KMT2ATDP1 | |
| SCHEMBL4857226 | 0.88 | MAP2K1 (0.52) | MAP2K1IDO1MEN1KMT2ATDP1 | |
| SCHEMBL4860279 | 0.87 | MAP2K1 (0.55) | MAP2K1IDO1MEN1KMT2ATDP1 | |
| SCHEMBL5382213 | 0.87 | MAP2K1 (0.59) | MAP2K1IDO1MEN1KMT2ATDP1 | |
| SCHEMBL4861835 | 0.87 | MAP2K1 (0.50) | MAP2K1IDO1MEN1KMT2ATDP1 | |
| SCHEMBL4862527 | 0.85 | MAP2K1 (0.52) | MAP2K1IDO1MEN1KMT2ATDP1 | |
| SCHEMBL4862685 | 0.85 | MAP2K1 (0.51) | MAP2K1IDO1MEN1KMT2ATDP1 | |
| SCHEMBL4862262 | 0.85 | MAP2K1 (0.56) | MAP2K1IDO1MEN1KMT2ATDP1 | |
| SCHEMBL6035638 | 0.84 | MAP2K1 (0.54) | MAP2K1IDO1MEN1KMT2ATDP1 | |
| SCHEMBL4857251 | 0.83 | MAP2K1 (0.74) | MAP2K1MAP2K2MAP2K5EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140291-B1 | COMBINATION CHEMOTHERAPY COMPRISING A MITOTIC INHIBITOR AND A MEK INHIBITOR | WARNER LAMBERT CO (US) | 2005-11-23 | — | — | EP | disclosed |
| EP-1140062-B1 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER LAMBERT CO (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-0993439-B1 | 4-BROMO OR 4-IODO PHENYLAMINO BENZHYDROXAMIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS | WARNER LAMBERT CO (US) | 2004-09-29 | — | — | EP | disclosed |