Sugi Predict

Sugi Predict / Compounds / Morpholine

Morpholine

Morpholine

SCHEMBL6231613

C1COCCN1.COc1cc(Nc2c(C#N)cnc3cc(-c4ccc(CN5CCOCC5)cc4)sc23)c(Cl)cc1Cl

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 20/20 0.86
▸ ABL1 P00519 2/20 0.78
▸ ABL2 P42684 2/20 0.78
▸ EGFR P00533 2/20 0.69
▸ MAP2K1 Q02750 2/20 0.69
▸ FYN P06241 1/20 0.69
▸ RAF1 P04049 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4900669 0.96 SRC (0.86) SRCABL1ABL2EGFRMAP2K1
Morpholine SCHEMBL6231281 0.95 SRC (0.79) SRCABL1ABL2EGFRMAP2K1
SCHEMBL4904386 0.93 SRC (1.00) SRCABL1ABL2EGFRMAP2K1
Morpholine SCHEMBL6227719 0.90 SRC (0.80) SRCABL1ABL2
SCHEMBL4902394 0.90 SRC (0.85) SRCABL1ABL2EGFRMAP2K1
Methylpiperazine SCHEMBL6232650 0.90 SRC (0.92) SRCABL1ABL2EGFRMAP2K1
SCHEMBL4898291 0.88 SRC (1.00) SRCABL1ABL2EGFRMAP2K1
SCHEMBL4932526 0.88 SRC (0.85) SRCABL1ABL2EGFRMAP2K1
SCHEMBL4892469 0.88 SRC (1.00) SRCABL1ABL2EGFRMAP2K1
SCHEMBL4904678 0.88 SRC (1.00) SRCABL1ABL2EGFRMAP2K1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004048386-A9 THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-b]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS WYETH CORP (US) 2005-07-14 — — WO disclosed