Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 3/20 | 0.46 |
| ▸ | F10 | P00742 | 3/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.46 |
| ▸ | F7 | P08709 | 3/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.46 |
| ▸ | F3 | P13726 | 2/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234094 | 0.90 | NPSR1 (0.48) | SMN1; SMN2LMNANPSR1MAPTPDE4A | |
| SCHEMBL6229069 | 0.87 | PDE4B (0.52) | F2SMN1; SMN2LMNANPSR1MAPT | |
| SCHEMBL498303 | 0.86 | CA12 (0.46) | SMN1; SMN2LMNAMAPTPDE4APDE4B | |
| SCHEMBL6228242 | 0.84 | PDE4B (0.43) | SMPD1SMN1; SMN2LMNAPDE4APDE4B | |
| SCHEMBL6227434 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2LMNAPDE4APDE4BPDE4C | |
| SCHEMBL6229711 | 0.84 | PDE4A (0.39) | SMN1; SMN2LMNANPSR1MAPTPDE4A | |
| SCHEMBL6229002 | 0.83 | PDE4B (0.39) | SMN1; SMN2LMNANPSR1MAPTPDE4A | |
| SCHEMBL6228363 | 0.82 | PDE4A (0.40) | SMN1; SMN2LMNANPSR1MAPTPDE4A | |
| SCHEMBL6231663 | 0.81 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6232542 | 0.81 | PDE4A (0.53) | SMPD1HDAC1HDAC8HDAC6F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933366-B1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2005-04-06 | — | — | EP | disclosed |
| US-6235739-B1 | ANTIINFLAMMATORY AGENTS; ANTIHISTAMINES; SKIN DISORDERS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0933366-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-08-04 | — | — | EP | disclosed |