SCHEMBL6232547

SCHEMBL6232547

CC(C)(C)c1c(O)c(OC(=O)O)cc(Cl)c1Cl

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.38
CYP2C19 P33261 1/20 0.34
AKR1C2 P52895 1/20 0.33
AKR1C1 Q04828 1/20 0.33
GLRA3 O75311 1/20 0.33
GLRB P48167 1/20 0.33
HPGD P15428 2/20 0.32
TSHR P16473 2/20 0.32
HSD17B10 Q99714 2/20 0.32
CASP1 P29466 1/20 0.32
TTR P02766 1/20 0.32
HIF1A Q16665 1/20 0.31
MAPK1 P28482 1/20 0.31
GABBR2 O75899 1/20 0.30
GABBR1 Q9UBS5 1/20 0.30
NR1H4 Q96RI1 2/20 0.30
RXRA P19793 1/20 0.30
RXRB P28702 1/20 0.30
RXRG P48443 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL47881 0.87 CYP2C19 (0.36) AKR1B1CYP2C19RXRARXRBRXRG
SCHEMBL6230446 0.79 CYP2C19 (0.38) CYP2C19AKR1C2AKR1C1TSHRHSD17B10
SCHEMBL6233296 0.74 POLB (0.36) GLRA3GLRBGABBR2GABBR1
SCHEMBL6257102 0.74 AKR1B1 (0.38) AKR1B1CYP2C19GLRA3GLRBHPGD
SCHEMBL6234052 0.73 TPMT (0.41) HPGDHSD17B10
SCHEMBL5589116 0.73 GLRA3 (0.32) GLRA3GLRBGABBR2GABBR1
SCHEMBL5589383 0.73 TTR (0.35) AKR1B1CYP2C19AKR1C2AKR1C1HPGD
SCHEMBL6231475 0.72 HIF1A (0.38) AKR1B1CYP2C19AKR1C2AKR1C1HPGD
SCHEMBL11569675 0.71 AKR1B1 (0.37) AKR1B1CYP2C19
SCHEMBL6232540 0.71 HSD17B10 (0.44) AKR1B1CYP2C19HPGDTSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1521758-A1 LATE TRANSITION METAL CATALYSTS FOR OLEFIN POLYMERIZATION AND OLIGOMERIZATION Exxonmobil Chemical Patents Inc. (US) 2005-04-13 EP claimed
WO-2004007509-A1 LATE TRANSITION METAL CATALYSTS FOR OLEFIN POLYMERIZATION AND OLIGOMERIZATION EXXONMOBIL CHEMICAL PATENTS INC. (US) 2004-01-22 WO claimed
EP-1521758-A1 LATE TRANSITION METAL CATALYSTS FOR OLEFIN POLYMERIZATION AND OLIGOMERIZATION Exxonmobil Chemical Patents Inc. (US) 2005-04-13 EP disclosed
WO-2004007509-A1 LATE TRANSITION METAL CATALYSTS FOR OLEFIN POLYMERIZATION AND OLIGOMERIZATION EXXONMOBIL CHEMICAL PATENTS INC. (US) 2004-01-22 WO disclosed