Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542191 | 0.88 | NPC1 (0.45) | NPC1RAB9ATSHRALDH1A1MEN1 | |
| SCHEMBL28030483 | 0.83 | KMT2A (0.55) | NPC1TSHRMAPTALDH1A1MEN1 | |
| SCHEMBL637534 | 0.79 | NPC1 (0.47) | NPC1ALOX15TSHRMAPTCYP1A2 | |
| SCHEMBL637961 | 0.79 | NPC1 (0.47) | NPC1TSHRMAPTALDH1A1MEN1 | |
| SCHEMBL10873786 | 0.72 | KAT2B (0.54) | L3MBTL1ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL29987696 | 0.72 | NPC1 (0.41) | NPC1ALOX15RAB9ATSHRMAPT | |
| SCHEMBL30142294 | 0.72 | NPC1 (0.47) | NPC1TSHRMAPTCYP1A2CYP3A4 | |
| SCHEMBL30142296 | 0.72 | NPC1 (0.47) | NPC1TSHRMAPTCYP1A2CYP3A4 | |
| SCHEMBL21431493 | 0.71 | NPC1 (0.53) | NPC1RAB9AMAPTALDH1A1MEN1 | |
| SCHEMBL27077673 | 0.71 | NPC1 (0.43) | NPC1RAB9AMAPTMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532149-A2 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PRODUCTION THEREOF AND THE USE OF THE SAME AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004018468-A2 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PRODUCTION THEREOF AND THE USE OF THE SAME AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-04 | — | — | WO | disclosed |