Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | LAP3 | P28838 | 2/20 | 0.54 |
| ▸ | ANPEP | P15144 | 2/20 | 0.54 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.54 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10635162 | 0.90 | POLB (0.61) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL9192833 | 0.90 | POLB (0.61) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL31126659 | 0.86 | KMT2A (0.63) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL2275011 | 0.85 | KMT2A (0.61) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL20589831 | 0.84 | KMT2A (0.55) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL7866857 | 0.84 | KMT2A (0.81) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| Hydrochloric Acid SCHEMBL27729415 | 0.83 | KMT2A (0.78) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL25681471 | 0.83 | KMT2A (0.61) | KMT2AMEN1TSHRCA12CA2 | |
| SCHEMBL10492080 | 0.82 | POLB (0.61) | KMT2ACYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL9188615 | 0.82 | POLB (0.54) | KMT2ACYP2D6CYP2C9CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049481-B1 | SYNTHETIC ANTINEOPLASTIC AGENTS DERIVED FROM DOLASTATIN 15 AND METHODS OF MAKING SAME | UNIV ARIZONA (US) | 2005-04-20 | — | — | EP | disclosed |
| US-6686445-B1 | ESTERIFICATION OF 2-HYDROXYISOVALERIC ACID AND TBOC-L-PROLINE; SALT FORMATION WITH TRIFLUORACETIC ACID; DEPROTECTING AND REACTING WITH N,N'-DIMETHYLVALINE | ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY | 2004-02-03 | — | — | US | disclosed |
| EP-1049481-A4 | SYNTHETIC ANTINEOPLASTIC AGENTS DERIVED FROM DOLASTATIN 15 AND METHODS OF MAKING SAME | UNIV ARIZONA (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1049481-A2 | SYNTHETIC ANTINEOPLASTIC AGENTS DERIVED FROM DOLASTATIN 15 AND METHODS OF MAKING SAME | ARIZONA BOARD OF REGENTS (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999015130-A2 | SYNTHETIC ANTINEOPLASTIC AGENTS DERIVED FROM DOLASTATIN 15 AND METHODS OF MAKING SAME | ARIZONA BOARD OF REGENTS, actingon behalf of ARIZ ONA STATE UNIVERSITY (US) | 1999-04-01 | — | — | WO | disclosed |