Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.65 |
| ▸ | PIM1 | P11309 | 5/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.65 |
| ▸ | TAOK1 | Q7L7X3 | 5/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.65 |
| ▸ | GSK3A | P49840 | 4/20 | 0.65 |
| ▸ | PRKX | P51817 | 4/20 | 0.65 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.65 |
| ▸ | CDK1 | P06493 | 3/20 | 0.65 |
| ▸ | CDK2 | P24941 | 3/20 | 0.65 |
| ▸ | GSK3B | P49841 | 3/20 | 0.65 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.65 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.65 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.65 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.65 |
| ▸ | CDK9 | P50750 | 3/20 | 0.65 |
| ▸ | CDK8 | P49336 | 3/20 | 0.65 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16712613 | 0.94 | CHEK1 (0.70) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL6234226 | 0.85 | CHEK1 (0.72) | CHEK1 | |
| SCHEMBL4852172 | 0.83 | CHEK1 (0.80) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4860069 | 0.83 | CHEK1 (1.00) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4849727 | 0.83 | CHEK1 (0.73) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4854888 | 0.82 | CHEK1 (0.69) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4849157 | 0.82 | CHEK1 (0.72) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4858729 | 0.81 | CHEK1 (0.78) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4850212 | 0.81 | CHEK1 (0.73) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4858765 | 0.80 | CHEK1 (0.69) | CHEK1AURKBPIM1CDK5TAOK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606268-A1 | HETEROCYCLIC KINASE INHIBITORS | Abbott Laboratories (US) | 2005-12-21 | — | — | EP | claimed |
| WO-2004076424-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-09-10 | — | — | WO | claimed |