Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.49 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.49 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079289 | 0.95 | MAPK14 (0.59) | BRAFMAPK14MAPK13PTK2MAPK12 | |
| SCHEMBL6080298 | 0.94 | MAPK14 (0.56) | BRAFMAPK14MAPK13PTK2MAPK12 | |
| SCHEMBL6079909 | 0.94 | MAPK14 (0.56) | FLT3MAPK14MAPK13PTK2MAPK12 | |
| SCHEMBL6079684 | 0.94 | MAPK13 (0.60) | FLT3BRAFMAPK14MAPK13PTK2 | |
| SCHEMBL6079363 | 0.92 | MAPK14 (0.49) | FLT3BRAFMAPK14MAPK13PTK2 | |
| SCHEMBL6078855 | 0.91 | BRAF (0.54) | FLT3BRAFMAPK14MAPK13PTK2 | |
| SCHEMBL6079432 | 0.85 | PTK2 (0.42) | BRAFMAPK14MAPK13PTK2MAPK12 | |
| SCHEMBL6080266 | 0.85 | MAPK14 (0.43) | BRAFMAPK14MAPK13PTK2MAPK12 | |
| SCHEMBL6079824 | 0.84 | PTPN1 (0.50) | BRAFMAPK14KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL6079268 | 0.83 | KCNJ6 (0.52) | BRAFKCNJ6KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005002673-A1 | RAF KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |