Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.31 |
| ▸ | PDE4A | P27815 | 2/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233772 | 0.70 | PDE4A (0.56) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6233764 | 0.58 | PDE4A (0.55) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL19415860 | 0.52 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL15753277 | 0.52 | PDE4D (0.55) | PDE4D | |
| SCHEMBL1616464 | 0.51 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL14164833 | 0.51 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL30362076 | 0.51 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL15753781 | 0.51 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1009756 | 0.51 | PDE4D (0.53) | PDE4D | |
| SCHEMBL15753276 | 0.50 | PDE4D (0.52) | PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515708-A1 | COMBINATIONS OF PDE-V INHIBITORS AND NK1 ANTAGONISTS FOR THE TREATMENT OF DEPRESSION | Pfizer Products Inc. (US) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003105815-A1 | COMBINATION OF PDE-V INHIBITORS AND NK1 ANTAGONISTS FOR THE TREATMENT OF DEPRESSION | PFIZER PRODUCTS INC. (US) | 2003-12-24 | — | — | WO | disclosed |