Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6230620 | 1.00 | DRD4 (0.49) | DRD4PRMT5WDR77PKMALDH1A1 | |
| SCHEMBL5582555 | 1.00 | DRD4 (0.49) | DRD4PRMT5WDR77PKMALDH1A1 | |
| SCHEMBL19462473 | 0.88 | DRD4 (0.60) | DRD4PRMT5WDR77PKMALDH1A1 | |
| SCHEMBL1531274 | 0.88 | DRD4 (0.54) | DRD4PRMT5WDR77PKMALDH1A1 | |
| SCHEMBL19461879 | 0.88 | DRD4 (0.60) | DRD4PRMT5WDR77PKMALDH1A1 | |
| SCHEMBL1531394 | 0.88 | DRD4 (0.54) | DRD4PRMT5WDR77PKMALDH1A1 | |
| SCHEMBL20786408 | 0.88 | MAPT (0.43) | DRD4PRMT5WDR77ALDH1A1HTT | |
| SCHEMBL13243222 | 0.84 | CYP19A1 (0.46) | DRD4PRMT5WDR77PKMALDH1A1 | |
| SCHEMBL7694427 | 0.83 | CYP19A1 (0.51) | DRD4PRMT5WDR77ALDH1A1CYP19A1 | |
| SCHEMBL4363583 | 0.81 | PRMT5 (0.44) | DRD4PRMT5WDR77PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004092181-A9 | HETEROCYCLIC MCHR1 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-01-27 | — | — | WO | disclosed |