Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5792063 | 0.82 | TSHR (0.53) | TSHRTP53EGLN1EGLN3BLM | |
| Fumaric Acid SCHEMBL6826914 | 0.82 | TSHR (0.53) | TSHRTP53EGLN1EGLN3BLM | |
| Maleic Acid SCHEMBL28227361 | 0.81 | APP (0.39) | TSHRTP53EGLN1EGLN3BLM | |
| Fumaric Acid SCHEMBL6095338 | 0.81 | TSHR (0.69) | TSHRTP53EGLN1EGLN3BLM | |
| Maleic Acid SCHEMBL11860272 | 0.81 | TSHR (0.69) | TSHRTP53EGLN1EGLN3BLM | |
| Fumaric Acid SCHEMBL6095324 | 0.81 | TSHR (0.69) | TSHRTP53EGLN1EGLN3BLM | |
| Fumaric Acid SCHEMBL3088427 | 0.80 | TSHR (0.50) | TSHRTP53EGLN1EGLN3BLM | |
| Fumaric Acid SCHEMBL3088432 | 0.80 | TSHR (0.50) | TSHRTP53EGLN1EGLN3BLM | |
| Maleic Acid SCHEMBL28847233 | 0.80 | TSHR (0.50) | TSHRTP53EGLN1EGLN3BLM | |
| SCHEMBL2467911 | 0.79 | BLM (0.42) | TSHRTP53EGLN1EGLN3BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007183-A2 | TREATMENT OF ANEMIA | THROMB-X NV (BE) | 2005-01-27 | — | — | WO | disclosed |