Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 8/20 | 0.35 |
| ▸ | CASP7 | P55210 | 8/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.35 |
| ▸ | USP2 | O75604 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.35 |
| ▸ | TSHR | P16473 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6240032 | 0.90 | RPS6KB2 (0.42) | RPS6KB2MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL6234238 | 0.87 | RPS6KB2 (0.44) | RPS6KB2MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL6237806 | 0.87 | CHEK2 (0.40) | RPS6KB2HSD17B10MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6261584 | 0.85 | RPS6KB2 (0.41) | RPS6KB2MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL6237665 | 0.82 | KMT2A (0.48) | KMT2ASMN1; SMN2CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL6233813 | 0.81 | RPS6KB2 (0.43) | RPS6KB2MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL6240919 | 0.79 | RPS6KB2 (0.44) | RPS6KB2MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL6240193 | 0.78 | MAPT (0.51) | RPS6KB2CYP2C9CYP3A4SRPK1 | |
| SCHEMBL6237136 | 0.77 | RPS6KB2 (0.44) | RPS6KB2MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL6236374 | 0.77 | RPS6KB2 (0.54) | RPS6KB2HSD17B10MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |