SCHEMBL6237058

SCHEMBL6237058

CCCCCCCC(C)(c1cc(Br)c(O)c(Br)c1)c1cc(Br)c(O)c(Br)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 3/20 0.57
TSHR P16473 2/20 0.57
HSD17B10 Q99714 2/20 0.57
CYP2C9 P11712 2/20 0.57
ALOX15 P16050 2/20 0.50
ALOX12 P18054 2/20 0.50
ALDH1A1 P00352 1/20 0.50
CYP3A4 P08684 1/20 0.50
HPGD P15428 1/20 0.50
CASP1 P29466 1/20 0.50
RECQL P46063 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
ESR1 P03372 1/20 0.44
CNR1 P21554 11/20 0.40
CNR2 P34972 11/20 0.40
CHEK1 O14757 1/20 0.40
DAPK3 O43293 1/20 0.40
RET P07949 1/20 0.40
PDGFRB P09619 1/20 0.40
PIM1 P11309 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10551142 0.93 TSHR (0.60) HIF1ATSHRHSD17B10CYP2C9ALOX15
SCHEMBL6232503 0.85 TSHR (0.64) HIF1ATSHRHSD17B10CYP2C9ALOX15
SCHEMBL2859192 0.82 ESR1 (0.49) ESR1CNR1CNR2
SCHEMBL2859215 0.82 ESR1 (0.49) ESR1CNR1CNR2
SCHEMBL10835507 0.82 ESR1 (0.49) ESR1CNR1CNR2
SCHEMBL10834634 0.82 ESR1 (0.49) ESR1CNR1CNR2
SCHEMBL10835161 0.82 ESR1 (0.49) ESR1CNR1CNR2
SCHEMBL6431647 0.80 ESR1 (0.48) HIF1ATSHRHSD17B10CYP2C9ESR1
SCHEMBL21232260 0.79 TSHR (0.57) HIF1ATSHRHSD17B10CYP2C9ALOX15
SCHEMBL14760082 0.78 HSD17B10 (0.55) HIF1ATSHRHSD17B10CYP2C9ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1274762-B1 POLYCARBONATE PREPARATION PROCESS DOW GLOBAL TECHNOLOGIES INC (US) 2005-05-11 EP disclosed
EP-1274762-A1 POLYCARBONATE PREPARATION PROCESS THE DOW CHEMICAL COMPANY (US) 2003-01-15 EP disclosed
WO-2001077204-A1 POLYCARBONATE PREPARATION PROCESS DOW GLOBAL TECHNOLOGIES INC. (US) 2001-10-18 WO disclosed
US-6225436-B1 REACTING PHOSGENE AND DIHYDRIC PHENOL; ADDING ACYL HALIDE; ADDING A CHAIN TERMINATOR TO THE REACTION MIXTURE; COMPLETING POLYMERIZATION REACTION THE DOW CHEMICAL COMPANY 2001-05-01 US disclosed
EP-0941268-A1 POLYCARBONATES THE DOW CHEMICAL COMPANY (US) 1999-09-15 EP disclosed
WO-1998022522-A1 POLYCARBONATES THE DOW CHEMICAL COMPANY (US) 1998-05-28 WO disclosed
US-RE35499-E MOLDED ARTICLES SUCH AS COMPACT DISKS THE DOW CHEMICAL COMPANY (US) 1997-04-29 US disclosed
EP-0699702-A2 Reaction products of carbonyl compounds and dihydric phenols THE DOW CHEMICAL COMPANY (US) 1996-03-06 EP disclosed
US-5128429-A Low temperature block polymerization without randomization RAYCHEM LIMITED (GB) 1992-07-07 US disclosed
EP-0154506-B1 PREPARATION OF ORGANIC POLYMERS RAYCHEM LIMITED (GB) 1992-02-05 EP disclosed
US-4210741-A Phenolphthalein-dihydroxy aromatic compound polycarbonates THE DOW CHEMICAL COMPANY (US) 1980-07-01 US disclosed
US-4195156-A ALKALI METAL SALTS OF DIHYDROXY- BENZENE MONO OR DI SULFONIC ACIDS AS COMONOMERS THE DOW CHEMICAL COMPANY (US) 1980-03-25 US disclosed
US-4168368-A STRESS RESISTANCE THE DOW CHEMICAL COMPANY (US) 1979-09-18 US disclosed
US-4156769-A Process for making polycarbonates using 1,1-dimethyl urea compounds as the catalysts THE DOW CHEMICAL COMPANY (US) 1979-05-29 US disclosed
US-4111910-A POLYCARBONATES HAVING CARBAMATE TERMINAL GROUPS THE DOW CHEMICAL COMPANY (US) 1978-09-05 US disclosed
US-4100139-A Polycarbonates incorporating epihalohydrin residues THE DOW CHEMICAL COMPANY (US) 1978-07-11 US disclosed
US-4059566-A Process for controlling the molecular weight of polycarbonates using ammonia or ammonia compounds THE DOW CHEMICAL COMPANY (US) 1977-11-22 US disclosed
US-4055544-A Process for making polycarbonates using ammonia or ammonia compounds as the catalysts THE DOW CHEMICAL COMPANY (US) 1977-10-25 US disclosed
US-4020045-A METALLIC SULFITES THE DOW CHEMICAL COMPANY (US) 1977-04-26 US disclosed
US-3992357-A THERMOPLASTIC THE DOW CHEMICAL COMPANY (US) 1976-11-16 US disclosed