Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 7/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | CASP1 | P29466 | 2/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8225236 | 0.84 | RPS6KB2 (0.51) | RPS6KB2MAPK14NPC1RAB9AHSD17B10 | |
| SCHEMBL8218830 | 0.84 | RPS6KB2 (0.51) | RPS6KB2MAPK14DHFRNPC1RAB9A | |
| SCHEMBL8381274 | 0.81 | ADORA2A (0.45) | RPS6KB2MAPK14NPC1RAB9ALMNA | |
| SCHEMBL8381406 | 0.81 | RPS6KB2 (0.43) | RPS6KB2MAPK14NPC1RAB9AHSD17B10 | |
| SCHEMBL7918254 | 0.80 | RPS6KB2 (0.42) | RPS6KB2MAPK14NPC1RAB9AHSD17B10 | |
| SCHEMBL7908001 | 0.80 | RPS6KB2 (0.42) | RPS6KB2MAPK14DHFRNPC1RAB9A | |
| SCHEMBL16027135 | 0.79 | RPS6KB2 (0.74) | RPS6KB2DHFRNPC1RAB9AHSD17B10 | |
| SCHEMBL31393470 | 0.79 | RPS6KB2 (0.74) | RPS6KB2DHFRNPC1RAB9AHSD17B10 | |
| SCHEMBL19066635 | 0.77 | RPS6KB2 (0.71) | RPS6KB2DHFRNPC1RAB9AHSD17B10 | |
| SCHEMBL6236262 | 0.77 | CYP1A2 (0.56) | RPS6KB2DHFRNPC1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | claimed |
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |