Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.64 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | FBP1 | P09467 | 2/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17815581 | 0.81 | EGFR (0.49) | EGFRAURKAMAPTSMN1; SMN2 | |
| SCHEMBL1896427 | 0.81 | TTBK1 (0.55) | EGFRKDRMAPT | |
| SCHEMBL4274133 | 0.79 | EGFR (0.55) | EGFRGRM1MAPK1ERBB2KDR | |
| SCHEMBL3061494 | 0.79 | EGFR (0.62) | EGFRMAPK1ERBB2FBP1PDGFRB | |
| SCHEMBL30683235 | 0.78 | EGFR (0.59) | EGFRGRM1MAPK1ERBB2KDR | |
| SCHEMBL26618910 | 0.78 | EGFR (0.59) | EGFRGRM1MAPK1ERBB2KDR | |
| SCHEMBL31299934 | 0.78 | EGFR (1.00) | EGFRGRM1ERBB2KDRAURKA | |
| SCHEMBL1096688 | 0.78 | EGFR (0.60) | EGFRGRM1MAPK1ERBB2KDR | |
| SCHEMBL8311292 | 0.78 | EGFR (0.77) | EGFRGRM1ERBB2KDRAURKA | |
| SCHEMBL19762918 | 0.78 | EGFR (0.69) | EGFRGRM1MAPK1ERBB2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009384-A2 | EGFR TYROSINE KINASE INHIBITORS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |