Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 7/20 | 0.69 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | NQO2 | P16083 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211545 | 0.91 | RPS6KB2 (0.58) | RPS6KB2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8213353 | 0.91 | RPS6KB2 (0.58) | RPS6KB2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL13595011 | 0.86 | RPS6KB2 (0.52) | RPS6KB2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL13595006 | 0.86 | RPS6KB2 (0.52) | RPS6KB2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL12669924 | 0.86 | RPS6KB2 (0.52) | RPS6KB2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL13594782 | 0.86 | RPS6KB2 (0.52) | RPS6KB2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL12669817 | 0.86 | RPS6KB2 (0.52) | RPS6KB2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL13594783 | 0.86 | RPS6KB2 (0.52) | RPS6KB2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6234080 | 0.79 | RPS6KB2 (0.64) | RPS6KB2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL577668 | 0.79 | NPC1 (0.46) | RPS6KB2MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |