Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | ADK | P55263 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6240193 | 0.87 | MAPT (0.51) | RPS6KB2MAPTSRPK1FYNRXFP1 | |
| SCHEMBL6237105 | 0.86 | RPS6KB2 (0.49) | RPS6KB2MAPTNPC1SMN1; SMN2SRPK1 | |
| SCHEMBL6236374 | 0.86 | RPS6KB2 (0.54) | RPS6KB2NPC1SMN1; SMN2SRPK1DHFR | |
| SCHEMBL6236517 | 0.81 | CYP2A6 (0.55) | RPS6KB2FYNDYRK1ADYRK1BPDGFRB | |
| SCHEMBL6233813 | 0.80 | RPS6KB2 (0.43) | RPS6KB2MAPTNPC1SMN1; SMN2SRPK1 | |
| SCHEMBL6256213 | 0.79 | RPS6KB2 (0.60) | RPS6KB2MAPTNPC1SMN1; SMN2SMPD3 | |
| SCHEMBL6237136 | 0.79 | RPS6KB2 (0.44) | RPS6KB2MAPTNPC1SMN1; SMN2PDGFRB | |
| SCHEMBL6240919 | 0.78 | RPS6KB2 (0.44) | RPS6KB2MAPTNPC1SMN1; SMN2PDGFRB | |
| SCHEMBL6233946 | 0.77 | DPP4 (0.50) | RPS6KB2SRPK1DHFRPDGFRBPDGFRA | |
| SCHEMBL6239563 | 0.76 | RPS6KB2 (0.53) | RPS6KB2MAPTNPC1SMN1; SMN2SRPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |