Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 10/20 | 0.57 |
| ▸ | PPARG | P37231 | 5/20 | 0.57 |
| ▸ | PPARA | Q07869 | 4/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | VDR | P11473 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617882 | 0.79 | PPARD (0.38) | PPARDPPARGPPARAPTPN1NPSR1 | |
| SCHEMBL6237739 | 0.76 | PPARD (0.56) | PPARDPPARGPPARAFFAR1 | |
| SCHEMBL4747275 | 0.75 | PPARD (0.59) | PPARDPPARGPPARAFFAR1NPSR1 | |
| SCHEMBL28781448 | 0.74 | PPARD (0.60) | PPARDPPARGPPARAPTPN1FFAR1 | |
| SCHEMBL12151275 | 0.74 | PPARD (0.56) | PPARDPPARGPPARAPTPN1NPSR1 | |
| SCHEMBL5441273 | 0.73 | MEN1 (0.37) | NPSR1RAB9ASMN1; SMN2KDM4ETHRB | |
| SCHEMBL2245562 | 0.73 | PPARD (0.55) | PPARDPPARGPPARAPTPN1NPSR1 | |
| SCHEMBL4414115 | 0.73 | PPARD (0.55) | PPARDPPARGPPARAPTPN1NPSR1 | |
| SCHEMBL4467452 | 0.73 | PPARD (0.58) | PPARDPPARGPPARAPTPN1KDM4E | |
| SCHEMBL6236889 | 0.72 | PPARD (1.00) | PPARDPPARGPPARAPTPN1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189895-B1 | THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2005-06-08 | — | — | EP | claimed |