Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.46 |
| ▸ | NEK2 | P51955 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5062107 | 0.92 | PLK1 (0.46) | PLK1NEK2FGFR1PLK4CHEK1 | |
| SCHEMBL5065832 | 0.84 | PLK1 (0.46) | PLK1NEK2FGFR1PLK4CHEK1 | |
| SCHEMBL3607331 | 0.79 | PLK1 (0.48) | PLK1NEK2FGFR1PLK4CHEK1 | |
| SCHEMBL5067437 | 0.78 | PLK1 (0.68) | PLK1NEK2FGFR1PLK4CHEK1 | |
| SCHEMBL5058123 | 0.78 | PLK1 (0.55) | PLK1NEK2FGFR1PLK4CHEK1 | |
| SCHEMBL5058295 | 0.78 | PLK1 (0.55) | PLK1NEK2FGFR1PLK4CHEK1 | |
| SCHEMBL5008887 | 0.77 | PLK1 (0.61) | PLK1NEK2FGFR1CSF1RPIM1 | |
| SCHEMBL3617056 | 0.75 | FGFR1 (0.53) | PLK1NEK2FGFR1PLK4CHEK1 | |
| SCHEMBL3615059 | 0.74 | PLK1 (0.53) | PLK1NEK2FGFR1PLK4CHEK1 | |
| SCHEMBL5062343 | 0.73 | FGFR1 (0.55) | PLK1NEK2FGFR1GSK3BPLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546137-A1 | BENZIMIDAZOL-1-YL-THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER | SmithKline Beecham Corporation (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004014899-A1 | THIOPHENE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-19 | — | — | WO | disclosed |