Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.57 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17244486 | 0.88 | PIK3CA (0.58) | PIK3CAGRIA2GRIA4PIK3CDPIK3CB | |
| SCHEMBL623815 | 0.88 | PIK3CA (0.47) | PIK3CAGRIA2GRIA4PIK3R1HSD17B10 | |
| SCHEMBL627237 | 0.83 | PIK3CA (0.60) | PIK3CAGRIA2GRIA4PIK3CDPIK3CB | |
| SCHEMBL10298687 | 0.82 | PIK3CA (0.54) | PIK3CAGRIA2GRIA4PIK3CDPIK3CB | |
| SCHEMBL15925947 | 0.80 | PIK3CA (0.55) | PIK3CAGRIA2GRIA4PIK3R1ALDH1A1 | |
| SCHEMBL623972 | 0.80 | PIK3CA (0.60) | PIK3CAGRIA2GRIA4PIK3CDPIK3CB | |
| SCHEMBL10308535 | 0.79 | PIK3CA (0.54) | PIK3CAGRIA2GRIA4PIK3CDPIK3CB | |
| SCHEMBL10298704 | 0.79 | PIK3CA (0.69) | PIK3CAGRIA2GRIA4KDM4EMTOR | |
| SCHEMBL10308536 | 0.79 | PIK3CA (0.51) | PIK3CAGRIA2GRIA4PIK3CDPIK3CB | |
| SCHEMBL10298736 | 0.79 | PIK3CA (0.40) | PIK3CAPIK3R1HSD17B10KDM4EMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603214-A1 | HETEROARYLS AND USES THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021696-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |